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These oxygen-independent killing mechanisms are directed toward thebacterial cell membrane, causing its breakdown and leakage.Neutrophils contain particularly large amounts of cationicantimicrobial proteins such as defensins and antimicrobialpeptides called cathelicidins. Variability ofhemodynamic responses to acute digitalization in chronic heart failure patients dueto cardiomyopathy and coronary artery disease.
The term prion is derivedfrom proteinaceous infectious particle (Prusiner, 1998).
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